Peptide Synthesis and Guide, Part Three

GHRH: Growth Hormone Releasing Hormone, somatocrinin or somatoliberin.

These GHRH-like peptides are produced in the hypothalamus and secreted to stimulate the release of human growth hormone (HGH). They are also called GRF or GHRF
(Growth Hormone Releasing Factor): also known as Growth Hormone Releasing Hormone (other synonyms, GRF and GHRF).

This is a continuation of the article Synthesis and Peptide Guide, Part Two

1. CJC-1295: A GHRH analogue modified to allow a longer life in the body. GHRH = ~7 days.

Dosage : 100mcg to 400mcg/day

The CJC-1295 peptide via DAC (Drug Affinity Complex) technology has a duration of action of approximately 7 days. It is therefore possible and justified to use this peptide once a week with excellent results.

However, as with some molecules, such as testosterone enanthate, it would be more appropriate to use split doses of CJC-1295 two and a half times per week to maintain high serum levels in order to achieve GH release and limit HGH fluctuations.

No serious side effects were reported in the test groups.

This peptide has the ability to stimulate growth hormone very significantly, and is much more advantageous than buying HGH from UG labs.

Another very positive aspect is that the CJC-1295 promotes deep sleep. Deep sleep is the portion of sleep responsible for the highest level of muscle growth.
Deep sleep is altered and significantly decreased in the elderly, or in people who work late at night.

CJC-1295 peptide has a use/effect ratio that exceeds other peptides currently on the market and is an excellent complement to MDP nutritional plans.

2. CJC-1293 (CJC-1295 without DAC or modified GRF [1-29]): GHRH analog.

Dosage: 100mcg/day minimum to 400mcg/day

To increase the stability and half-life of GRF (1-29) four amino acid changes were made to its structure. These changes increase the half-life beyond 30 minutes which is more than sufficient to exert a sustained effect that will maximize a GH pulse. This form is often called tetrasubstituted (1-29) (or modified) GRF. Basically it is the sermorelin that we have evolved to maximize the “pulse” of gh. Because of its short half-life, it must be injected more often than its close cousin (cjc1295 DAC), 3 to 4 times a day.

3. Sermorelin (or GRF [1-29]): Fragment of amino acids 1 to 29 of human endogenous GHRH without modifications.

Dosage: between 200 and 500mcg/day

Sermorelin, sometimes called GRF 1-29, is an analogue of growth hormone or GHRH.
It is a 29 amino acid polypeptide representing fragment 1 to 29 of endogenous human growth hormone and is likely to be entirely the shortest functional fragment of GHRH. It is used as a “substitute” for growth hormone secretion. It is also used extensively in anti-aging therapy often along with testosterone in men. One of the safest alternatives to human growth hormone.

Note from Thor49 : it is useless and ineffective to take directly unmodified GHRH ([1-44]) or its truncated version (GRF [1-29], Sermorelin) which have such a short half-life that they are degraded before reaching the pituitary.
Prefer the Mod GRF[1-29] (CJC-1293 also called CJC-1295 without DAC) or the CJC-1295 with DAC.

GHRP/GHRH solution: for a better synergy they must be combined!

Taking 100 to 200mcg of a GHRP analogue + 100 to 400mcg of a GHRH analogue together has real and beneficial benefits. To be effective, this mixture should be spread over the day, in 3 or 4 doses divided over the day:
In the morning: 100 to 200mcg GHRP + 100 to 400mcg GHRH
Optional: Mid-morning or mid-day: 100 to 200mcg GHRP + 100 to 400mcg GHRH
In PWO: 100 to 200mcg GHRP + 100 to 400mcg GHRH
At bedtime: 100 to 200mcg GHRP + 100 to 400mcg GHRH

These injections must be spaced at least 3 hours apart and administered on an empty stomach, followed by a short period of 15 to 30 minutes without

Note from Thor49: I think 8 weeks of GHRP/GHRH should be the maximum.

Examples of peptide plans:

HGH alone:

start with 2ui/day and increase by 1ui/day to reach the chosen dose.
Then in view of its half-life, it is necessary to space out the injections but the last one must be spaced out from the bedtime.
2-3ui in the morning and 2-3 ui in the afternoon work very well.

IGF1-LR3 alone:

40 to 100mcg in pwo (1mcg per kilo of body weight)

Note Thor49 : don’t forget the shake pwo.
start with 40mcg to test his reaction then increase the dose to 1mcg per kilo of body weight. The first time you use it, small amounts are enough to get good results.


Days off: 400-500mcg PEG MGF
Day one: immediately in PWO: 100-200mcg of MGF (not pegylated), 30 minutes later between 60 to 100mcg of IGF1-LR3 with “special pwo” shake.

Ipamorelin/GHRp6: 4 to 8 weeks

In the morning: 100mcg ipamorelin + 200mcg GHRP-6
In PWO: 100mcg ipamorelin + 200mcg GHRP-6
At bedtime : 100mcg ipamorelin + 200mcg GHRP-6

CJC1293/GHRP-6: 4 to 8 weeks

In the morning: 100mcg CJC1293 + 200mcg GHRP-6
In PWO: 100mcg CJC1293 + 200mcg GHRP-6
At bedtime : 100mcg CJC1293 + 200mcg GHRP-6

Gavin Kane’s Peptide Planning:

Bulk 1: 3x per week

PWO: 10-15iu HGH (small muscles), 20 minutes after 30mcg IGF1-LR3 then 5 minutes after 5-12ui humalog then shake pwo

Note Thor49 : take 60grs whey + 80-100grs of sugars (dextrose, grape juice etc…).
1 hour later: a solid meal consisting of lean meat and complex carbohydrates, fat will be reduced to a minimum.

Bulk 2: 3x per week

PWO: 10-15iu HGH (small muscles), 5 minutes after single MGF 400-500mcg then 30 minutes after 40-60mcg IGF1-LR3 then shake pwo

Note Thor49 : take 60grs whey + 80-100grs of sugars (dextrose, grape juice etc…).
1 hour later: solid meal consisting of lean meat and complex carbohydrates, green salad + olive oil