T3 Post Cycle

Like many things in our sport, T3 or Liothyronine has its own myths.

Small presentation:

The thyroid gland is the largest of the endocrine (hormone-secreting) glands in the human body.
It secretes :

* T3 or triiodothyronine in very small quantities;
* T4 or thyroxine;
* Calcitonin is involved in calcium metabolism.

The production of these hormones is regulated by thyroid-stimulating hormone (TSH), produced by the pituitary gland. The greatest production of T3 is obtained by the conversion of T4 in the liver, for the largest amount, and the intestines for the rest. The thyroid produces T3 directly for only 10 to 20%.

I will voluntarily not dwell on T4, to avoid the eternal question: T3 or T4 during HGH?
Basically for me this answer remains simple: according to our analysis we must be able to advise.

T3: Liothyronine sodium

Liothyronine is the synthetic form of the natural levo-thyroid hormone T3 (LT3) and has all its biological activities: elevation of basal metabolism, acceleration of heart rate, inhibition of TSH secretion.

Pharmacoclinical studies have shown that T3 has a shorter latency time and greater intensity of action than T4.

In addition, it is important to know that the thyroid axis returns to normal within a short period of time. Of course, depending on the predisposition of each person, this time will be more or less long. Again, regular testing is important.

So after a cycle including T3, what would be the adjuvants to facilitate a return to normal?
There are many natural supplements that can help with this. Which ones?

Coleus forskolii: 250 mg of a 10% standardized extract of forskohlii twice a day for eight weeks

Caution: people following a treatment against ulcer, tension, blood coagulation should ask their doctor before using the coleus.

It is a plant native of India, of the family of Labiatae, with large toothed leaves with dominant red purple, with central vein strongly marked with margin irregularly tinted of acid green and with inflorescence in blue spike.

Several studies have shown that forskolin stimulates adenylate cyclase in thyroid membranes, thereby increasing cAMP3 accumulation. Increasing cellular cAMP has a number of physiological and biochemical effects, including stimulating thyroid function.

Among other things, increased levels of cAMP activate cAMP-dependent protein kinase, which in turn activates hormone-sensitive lipase that breaks down fat and releases it into the bloodstream as free fatty acids. This process is commonly referred to as the cAMP cascade or lipolytic cascade4. Forskolin has been shown to increase thyroid hormone production and stimulate its release. By this mechanism, it strengthens the metabolism, which may explain the mechanism by which it promotes weight loss. Its normalizing effects on thyroid function may also contribute to its antidepressant action, depression being a common feature of hypothyroidism.

L-TYROSINE: 250 to 750mg/day

L-tyrosine, an amino acid, is essential for healthy and normal thyroid function. It uses it together with iodine to produce the thyroid hormones of which it is a biological precursor. Important for the structure of almost all proteins in the body, L-tyrosine attaches to iodine atoms to form thyroid hormones.

The body produces it naturally from other amino acids. But, with the years, this production becomes scarce and insufficient to meet the needs of the thyroid. A supplementation is therefore important to maintain its normal activity.

Guggulsterones: 500mg, 3 times a day (standardized extract at 5%)

The guggulsterones, extracted from Commiphora mukul, have been used by Ayurvedic medicine for thousands of years to treat arthritis, inflammation, bone fractures, overweight or lipid metabolism disorders.

The majority of studies on guggulsterones have been done on their ability to lower cholesterol. They have also been identified as promoting weight loss. They activate lipolytic enzymes and increase T3 levels, probably by increasing the conversion of T4 to T3 in the liver and directly stimulating the thyroid gland. Their ability to stimulate the thyroid gland may partly explain why they can act on cholesterol levels and promote weight loss by increasing the body’s metabolism.

Administered to albino rats (1 g per 100 g of body weight), they cause an increase in iodine consumption by the thyroid and stimulate the activities of thyroid peroxidase and protease, as well as oxygen consumption by isolated slices of liver and biceps muscle.

Studies have shown that they can increase blood levels of thyroid hormones. In particular, they raise the T3 to T4 ratio. At the same time, a decrease in normal radical lesions of the liver is observed. This finding is particularly interesting, as the liver is the primary site of T4 storage and T3 regeneration.

When thyroid activity is stimulated and the metabolic rate returns to normal, weight loss can occur more easily and quickly.

Subjects followed a six-week weight-loss program that included diet, exercise and, for some of them, a nutritional supplement containing guggulsterones. The subjects who took a guggulsterone nutritional supplement lost nearly 5 kg of fat compared to only 1.5 kg for those who did not supplement. At the same time, the activity of their thyroid gland was increased by 8 to 10%.

Iodine: 225 to 1000mcg/day

The body needs iodine to produce thyroid hormones; mild to moderate iodine deficiencies can lead to the development of a goiter (an abnormal enlargement of the thyroid gland). The thyroid is the only part of the body that can capture and retain iodine. It is an essential component of the T3 and T4 hormones. To meet the body’s need for thyroid hormones, the thyroid gland traps iodine from the blood and incorporates it into thyroid hormones.

Other minerals including iron and zinc are essential for normal thyroid hormone metabolism. The coexistence of deficiencies in these elements can disrupt thyroid function.

Zinc: 25 to 50mg/day

Zinc increases thyroid function; its levels are generally high in hyperthyroidism and low in hypothyroidism. In animal studies, zinc, selenium and/or iodine deficiencies have distinct effects on thyroid metabolism and structure. Zinc deficiency is associated with an approximately 30% decrease in serum T3 and free thyroxine concentrations compared to controls with normal zinc status. In patients with low T3 levels, zinc may play a role in thyroid hormone metabolism and may contribute to the conversion of T4 to T3. This effect was confirmed in a study of zinc-deficient college girls.

In sedentary men, exercise has the effect of lowering their testosterone and thyroid hormone levels. Zinc supplementation prevents this decrease

Selenium: 300 to 1000mcg/day

Selenium is more concentrated in the thyroid gland than in any other organ, showing that it is essential for its normal functioning. It acts as an antioxidant that protects the thyroid gland and as a cofactor that facilitates the production of thyroid hormones, promoting the conversion of T4 to T3.

The formation of thyroid hormones takes place in the membranes of thyroid cells, called thyrocytes. The process requires the presence of selenium as a cofactor. In the process, the enzyme thyroid peroxidase (TPO) prepares the binding of iodine to tyrosine to form thyroid hormone. Normal TPO activity generates a large number of free radicals in the thyroid gland in the form of H2O2 and lipid peroxides. They must be inactivated by selenium enzymes so that thyroid hormone production is not disrupted and the thyroid gland is not inflamed.

In an animal model, long-term selenium deficiency leads to thyroid cell death. It also affects the generation of free radicals, the conversion of T4 to T3 and the autoimmune process.

Selenium is a component of the enzyme I 5′-deiodinase which helps convert T4 to T3 in peripheral tissues. Selenium deficiencies could therefore disrupt thyroid function and promote hypothyroidism. In elderly patients, a decrease in the conversion of T4 to T3 in peripheral tissues with a lower T3/T4 ratio and overt hypothyroidism is frequently observed. A study of 109 euthyroid subjects (with normal levels of thyroid activity) indicates that decreased conversion of T4 to T3 in peripheral tissues is related to insufficient selenium status in the elderly.

Selenium supplementation is also beneficial in cases of iodine deficiency. Researchers believe that selenium deficiency exacerbates the effects of iodine deficiency on thyroid function and that an adequate selenium nutritional status may help protect against some of its neurological effects.

Magnesium: 180-200mg, three times a day

One study examined the effect of magnesium on thyroid hormones in sedentary and taekwondo subjects in a four-week training program. Two groups (one of sedentary subjects, the other of subjects practicing 90 to 120 minutes of taekwondo five days a week) received 10 mg/day per kilogram of body weight of magnesium. A third group practiced the sports activity without taking magnesium supplements. The results showed that the practice of an athletic activity until exhaustion provokes in sedentary people as well as in trained athletes a decrease in the activity of the thyroid and that a magnesium supplementation prevents this reduction in activity.

B vitamins

In hypothyroid subjects, folic acid levels appear to be depressed. Similarly, serum homocysteine concentrations are higher in women with hyperthyroidism than in those without. A study of 50 hypothyroid patients and 46 hyperthyroid subjects shows that folate levels are lower in hypothyroid patients and higher in hyperthyroid patients. Another study examined 31 young hypothyroid women and 30 healthy young women and assessed their plasma concentrations of total homocysteine, folate and cobalamin before and after treatment with L-thyroxine. This treatment lowered homocysteine levels but had no effect on folate and cobalamin levels.

I know that at smart city, he had a thyro formula supplement, rather well dosed.

Obviously, these are not the only supplements, there are a plethora of them but these are, in my opinion, the main ones.