Peptides Guide: SYNTHESIS OF THE DIFFERENT PEPTIDES, USES AND APPLICATION METHODS
What is a peptide? A peptide is a polymer of amino acids linked together by peptide bonds.
The different peptides that interest us:
HGH: Human Growth Hormone
Dosage (for a conventional bodybuilder, not for a BB who prepares Mr “O”) between 2ui and 6ui/day spread over the day but far from the bedtime to not interfere
on its own natural production.
Growth hormone, somatropin or somatotropin, is a polypeptide hormone secreted by somatotropic cells in the anterior pituitary gland that stimulates growth and cell reproduction in humans and other vertebrates.
Its effects (not exhaustive of course):
– Reduction of adipose tissue and particularly abdominal fat. (The reduction of abdominal fat is the most pronounced effect in many people).
– Decrease in hip circumference. (The significance of fat removed mainly from around the waist where it is associated with a high risk of coronary heart disease).
– Increase in muscle mass.
– Reduction of skin aging. (In addition to the Melanotan and MT-II).
– Dynamic recovery of certain internal organs that have atrophied with age.
– Strengthening of the immune system.
– Increased sense of well-being.
– Stimulation of the production of bone marrow cells that produce red blood cells.
– HGH peptide slows the progression of cardiovascular disease, and reduces the risk of heart attack, in people with naturally low and below average levels of growth hormone for the person’s age.
HGH peptide may also slow the progression of cardiovascular disease by improving the cholesterol profile.
Negative effects: acromegaly, hypoglycemia, thyroid disorders, growth disorders before the age of 20 that can lead to gigantism.
Thor49’s advice: An addition of L-Tyrosine or even T3 (I prefer the latter: 12.5mcg to 25mcg) is highly recommended. One must also take into account the half-life of GH, approximately 2 to 4 hours, during which time natural GH secretion will be inhibited. The best times to take it are on an empty stomach upon waking up and post-workout, not before sleeping in order not to block one’s own GH production.
– Igf1 : I will speak here about the igf1-lr3 because the other variants of this last one are of a still too recent use to have a balanced feedback.
Dosage: 1mcg per kilo of body weight in PWO with a shake of 80 to 100grs of high GI carbohydrates and 30 to 60grs of whey.
IGFs (short for insulin-like growth factor), specifically IGF-1 and IGF-2, are peptide hormones with a chemical structure similar to insulin. These hormones are mainly secreted by the liver and released into the bloodstream.
IGF-1 has a chemical formula close to that of insulin, which is why its anabolic action is similar to that of insulin. Indeed, IGF-1 stimulates – just like insulin – the arrival of nutrients in the muscles, which has the effect of increasing protein synthesis, hence muscle mass gain. This anabolic action also comes from the fact that IGF-1 is the messenger of the growth hormone to order the cells to multiply. This means that the more growth hormone the body contains, the more IGF-1 it contains.
This hormone also has other effects, different from those of insulin. First of all, while IGF-1 does not regulate blood glucose levels like insulin does, it does help combat hypoglycemia or hyperinsulinemia by bringing insulin levels in the body back to normal. IGF-1 is appreciated by bodybuilders for its ability to give a striated look while providing good strength. An athlete can expect a reduction of about 5% of fat in the body after one month of treatment. IGF-1 also lowers cholesterol levels and increases the production of red blood cells in the blood. This last property facilitates muscle oxygenation, which makes the bodybuilder more energetic during training.
Thor49’s advice: It is the only peptide (for the moment) that can be reconstituted with acetic acid (aa) or white vinegar added with bacteriostatic water (bw). 1ml of aa + 9ml of bw.
In PWO for those who want to couple with GH, I advise to do GH immediately then wait 20min and finally take igf1-lr3 to create the famous synergy of the two peptides.
A duration of use of 4 weeks followed by 4 weeks off gives more than positive results.Thor49’s warning about Insulin.
The subject remains far too sensitive, and the molecule delicate to treat, to venture into a use that can lead, even with experience to sudden death. I am therefore only talking about it for information purposes.
Insulin
Dosage: There are many different ways to take insulin. Most athletes take it right after training. The usual dose is 1 i.u. for 11 to 22 lbs of dry weight. Of course, it is necessary to start with small doses, and increase gradually. For example, start at 2 i.u. and increase by 1 i.u. after each workout. This allows the bodybuilder to safely find the right dose for him or her, as the appropriate dose for each individual depends on insulin sensitivities and the use of other products.
For example, if an athlete is taking growth hormone and thyroid hormone at the same time as insulin, it will take a much higher dose for the insulin to have an effect. Humulin R, one of the best known insulins, is administered by subcutaneous injection and exclusively with a U100 syringe. It would be dangerous to use another syringe because other syringes do not measure the dose accurately. The subcutaneous injection is done by pricking a fold of skin on the abdomen or in the thigh or triceps if you want to accelerate the effect of the product.
Insulin is a hormone produced by the pancreas that regulates the level of glucose in the blood. It is used medically in the treatment of diabetes.
Insulin is very popular with bodybuilders because it has an anabolic effect. Indeed, with well timed injections, insulin promotes the arrival of nutrients in the muscles.
The main risk for an insulin user is hypoglycemia. This occurs when blood glucose levels become too low. Before an athlete starts taking insulin, it is absolutely vital that they know the warning signs that indicate possible hypoglycemia: hunger, drowsiness, blurred vision, depression, dizziness, sweating, heart palpitations, tingling in the hands, feet, lips or tongue, dizziness, inability to concentrate, headaches, sleep disturbances, anxiety, slurred speech, abnormal behavior, slurred speech, personality changes. If one or more of these warning signs appear, you should immediately take a sweetened drink or a sweetened bar (these foods contain carbohydrates).
This will compensate for the onset of hypoglycemia and prevent severe hypoglycemia. A hypoglycemic attack is a very serious matter and a doctor should be notified immediately if it occurs.
The symptoms and stages of a hypoglycemic crisis are, in order, disorientation, seizure, unconsciousness and then DEATH.
The importance of carbohydrates.
Most athletes bring their insulin to the gym. Insulin should be kept cold, but it can be stored in a gym bag if it is kept away from heat. The injection is done immediately after the training. The athlete must consume a carbohydrate drink within 15 minutes, at a rate of at least 10 g of carbohydrates per U.l of injected insulin. In general, he adds creatine monohydrate to his drink because insulin promotes the penetration of creatine into the muscles. Approximately 1 hour after the injection, a meal or protein should be taken. Both the drink and the meal (or protein) are totally essential. Without them, blood sugar levels drop dangerously low and hypoglycemia occurs quickly.
About sleep.
Athletes often want to sleep after the injection. This may be the beginning of hypoglycemia, and more carbohydrates should be consumed. The temptation to go to sleep should be avoided at all costs because it is during sleep that hypoglycemia can reach its critical threshold. By not being alerted by the warning signals, the sleeping person is at high risk of hypoglycemia without anyone noticing. Humulin R acts for about 4 hours with a peak after the first 2 hours. It is therefore prudent not to sleep for 4 hours after the injection.
The risks associated with the various practices.
Rather than waiting until the end of a workout, some people prefer to inject 30 minutes before the end of the session. This makes insulin more effective at delivering glycogen to the muscles, but it also increases the risk of hypoglycemia. Some even inject a few I.U.s before training to increase their energy. This is an extremely risky practice and is reserved for users who are used to insulin. Finally, some people inject their insulin in the morning when they wake up. They then consume a carbohydrate drink and eat breakfast within an hour. There are athletes for whom this practice will be very beneficial when building muscle mass but others will tend to store unnecessary fat.
Thor49’s advice: Insulin is only used by a certain bodybuilding “elite”, so I strongly advise against its use unless you are sure to be on the podium between Jay Cutler and the other stars…
MGF: Mechano Growth Factor
Dosage: 100-200mcg per day.
Dose administered symmetrically in the muscles worked previously in the session.
50/50mcg to 100/100mcg local intramuscular.
Administration within one hour of the session (for non-PEGylated FGM!).
MGF is in fact a variant of IGF1 but its sequence is different from systemic IGF-1 produced by the liver. MGF is expressed by mechanically stimulated muscle and is involved in tissue repair. It is expressed as “pulses” following muscle damage and is involved in the activation of muscle satellite cells.
MGF is a member of the IGF family, but in the case of MGF, part of the peptide (very specific) acts as a distinct growth factor involved in the recruitment and activation of muscle satellite (stem) cells.
In addition, the IGF-derived form of MGF retains its IGF-1 receptor domain and therefore improves muscle mass.
MGF has shown its ability to stimulate muscle mass by improving tissue growth capacity, has shown its ability to activate muscle stem cells (myoblasts or satellite cells). MGF has a positive action on the regulation of protein synthesis. MGF induces rapid muscle hypertrophy, MGF has considerable potential as a treatment for muscle wasting.
Since it is a variant of IGF1, MGF is very adaptable and therefore acts in synergy with its close cousin. In other words, repeated administrations of MGF and IGF-1 Lr3 allow a rapid increase in muscle growth.
– PEG MGF: PEGylation is the act of attaching a polyethylene glycol structure (PEG) to another larger molecule (in this case, MGF). The HORSE acts as a protective coating and the theory here is that this will allow the FGM to be carried by the blood stream without being broken down.
Dosage: 400-500mcg on non-training days.
Note from Thor49: An excellent stack includes the famous IGF1-LR3/MGF/MGF PEG peptides.
Days off: 400-500mcg PEG MGF
Day one: immediately in PWO: 100-200mcg of MGF (not pegylated), 30 minutes later between 60 to 100mcg of IGF1-LR3 with “special pwo” shake.
